new insight in ezetimibe /garlic combination in hypercholesterolemic mice
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منابع مشابه
Antioxidant activity of ezetimibe in hypercholesterolemic rats
Hypercholesterolemia is a significant risk factor for the development of coronary heart disease, which is a leading cause of mortality and morbidity in many countries. Results from several landmark clinical trials have shown that, 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors (i.e., statins) effectively and significantly reduce elevated serum low-density lipoprotein cholesterol (LDL...
متن کاملEfficacy of ezetimibe as monotherapy or combination therapy in hypercholesterolemic patients with and without diabetes.
Ezetimibe selectively inhibits dietary and biliary cholesterol absorption and reduces serum cholesterol levels when administered alone (monotherapy) and along with common lipid-regulating agents (combination therapy). To evaluate the effect of ezetimibe therapy on the lipid profile, glucose metabolism, and levels of cholesterol absorption and synthesis markers, we administered 10 mg ezetimibe t...
متن کاملNew insight into the immunomodulatory mechanisms of Tretinoin in NMRI mice
Objective(s):Recent evidence have proposed that Tretinoin produced in the gut preferentially promote differentiation of FoxP3+Treg cells but inhibits Th17 lymphocytes, and this may be the main immunomdulatory mechanism of Tretinoin in vivo. This study was done to investigate the effects of Tretinoin in outbred white mice after challenge with sheep red blood cells (SRBC). Materials and Methods:...
متن کاملDelayed arteriogenesis in hypercholesterolemic mice.
BACKGROUND Hypercholesterolemia has been reported to inhibit ischemia-induced angiogenesis. To address its effects on arteriogenesis, we investigated arterial growth in hypercholesterolemic low-density lipoprotein receptor(-/-)/ApoB-48(-/-) (HCE) mice. METHODS AND RESULTS The extent and the time course of arteriogenesis after femoral artery ligation was evaluated in HCE and strain-matched con...
متن کاملEffect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice
BACKGROUND Garlic is one of the medicinal plants which has showed beneficial effects on atherosclerosis risk factors. The liver X receptor α (LXRα) is an important regulator of cholesterol, triglyceride and glucose homeostasis that belongs to the nuclear receptor superfamily. In this study we investigated the effect of garlic on lipid profile, glucose as well as LXRα expression in intestine and...
متن کاملnew insight into the immunomodulatory mechanisms of tretinoin in nmri mice
objective(s):recent evidence have proposed that tretinoin produced in the gut preferentially promote differentiation of foxp3+treg cells but inhibits th17 lymphocytes, and this may be the main immunomdulatory mechanism of tretinoin in vivo. this study was done to investigate the effects of tretinoin in outbred white mice after challenge with sheep red blood cells (srbc). materials and methods:...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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